Thursday, March 7, 2013

A look at what NKorea vow to scrap armistice means

SEOUL, South Korea (AP) ? The armistice that ended the Korean War in 1953 is, at best, a fragile thing: The countries overseeing it have formally accused each other of more than 1.2 million violations.

But North Korea's threat to scrap the cease-fire next Monday still matters because the armistice is the key document blocking hostilities on the Korean Peninsula, which technically has remained in a state of war for six decades.

If North Korea follows through on its threat to nullify the document that set up the heavily armed buffer zone between the Koreas, it could drive badly frayed relations even lower. The threat comes as diplomats at the U.N. negotiate sanctions aimed at punishing Pyongyang for its recent nuclear test and as allies Washington and Seoul plan massive war games set to start Monday.

Here's a look at what the North's threat could mean for the Korean Peninsula's fragile peace:

ON THE GROUND:

The armistice signed on July 27, 1953, set up an apparatus meant to govern a cease-fire ending the war. It can be seen most clearly at the Demilitarized Zone between North and South.

The armistice called for the creation of a military demarcation line and the DMZ around it ? a 4-kilometer (2.5-mile) -wide "buffer zone," with one side controlled by the American-led U.N. Command and the other side by North Korea.

The armistice prohibited "hostile acts" within or across the zone. As a hotline between the sides, it set up a military truce commission at the Panmunjom village that straddles the DMZ.

By scrapping the armistice, North Korea would be effectively refusing to recognize the DMZ, which is a violent place even with the rules of the armistice in place: Hundreds of troops serving under the U.N. command have died in the buffer zone over the years.

"North Korea wants to show it can attack South Korea at any time," said analyst Cheong Seong-jang at the private Sejong Institute in South Korea. "The chance for limited war ... has increased."

The South Korean military says North Korea has violated the armistice by deploying machine guns inside the DMZ, triggering exchanges of gunfire along the border and digging infiltration tunnels.

North Korea has accused the U.S. and South Korea of deploying heavy weapons and combat personnel inside the DMZ, conducting war maneuvers targeting the North and firing at North Korean fishing boats near the western sea boundary.

North Korea said this week that its Korean People's Army Supreme Command will stop all activities at the "Panmunjom mission of the KPA, which was tentatively established and operated by it as a negotiating body for establishing a peace-keeping mechanism on the Korean Peninsula."

The North also vowed to cut off a phone line linking North Korea and the United States at Panmunjom.

FEAR IN SEOUL, TALKS IN WASHINGTON?

American and South Korean analysts see the threat as an attempt to win direct aid-for-disarmament talks with Washington by raising fears of war on the peninsula. North Korea wants such negotiations in part to secure much-needed aid and to force the removal of 28,500 U.S. troops stationed in the South.

"By disavowing the armistice, North Korea is sending a reminder about just how flimsy the peace regime on the Korean Peninsula is," said John Delury, a professor at Yonsei University in Seoul. "In Pyongyang's mind anyhow, this serves to reinforce their argument that formal peace talks and a new security architecture is a prerequisite to full denuclearization."

But it also stirs fear among South Koreans.

People in Seoul are famously unimpressed with North Korean bluster, but the DMZ is only an hour's drive from the bustling capital.

"The North Korean threat is a blade that cuts at both the United States and at South Koreans," said Lee Ho-chul, a North Korea analyst at Incheon National University in South Korea. "For South Koreans, it's a threat that North Korean forces will now ignore the military demarcation line. That can cause worries among ordinary South Koreans."

Actually tearing up the cease-fire could remove an important psychological shield for South Koreans as they pursue building one of Asia's premier economies.

"I'm worried North Korea may be trying to provoke a war," restaurant worker Lee Hui-sook said in Seoul when asked about the threat. "I feel much more insecure than in the past about whether my country can handle North Korea."

BLUFF OR PROMISE?

Since the 1990s, North Korea has frequently threatened to scrap the armistice. In 1996 it followed such a threat by sending hundreds of armed troops into Panmunjom. South Korea boosted its surveillance to its highest level in 15 years, and the troops later withdrew.

The context of the latest threat, however, is important.

This one follows five years of abysmal ties between the Koreas, during which Seoul's hardline president was met by North Korean nuclear and rocket tests. Attacks blamed on Pyongyang in 2010 killed 50 South Koreans.

New President Park Geun-hye is settling into office in Seoul after making promises to re-engage the North, but with a vague policy about how to get that done.

The North's latest statement is unusually specific, warning of "lighter and smaller nukes" and "surgical strikes," and is seen as noteworthy by Seoul because a senior military official from the Korean People's Army Supreme Command issued the threats on state TV.

But North Korea has made surprisingly specific threats in the past, including vowing to destroy the headquarters of major South Korean newspapers last year, and then later backed away.

"They make such statements a few times in the average year," Andrei Lankov, a professor at Kookmin University in Seoul, said. "Perhaps it makes them feel good. But practical impact? Zero."

MILITARY REACTION IN SEOUL

South Korea's military is taking the North's threats seriously.

Army Maj. Gen. Kim Yong-hyun, an official with the Joint Chiefs of Staff, said in nationally televised remarks Wednesday that North Korea was told that the drills starting Monday, which involve 10,000 South Korean and 3,500 U.S. forces, are defensive.

He also indicated that North Korea and its military leadership will suffer if there are any attacks.

"If North Korea goes ahead with provocations and threatens the lives and safety of South Koreans, our military will strongly and sternly retaliate against the command and its supporting forces," he said.

Source: http://news.yahoo.com/look-nkorea-vow-scrap-armistice-means-111400329.html

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Wednesday, March 6, 2013

Rolls-Royce Wraith picks gears using GPS, keeps your Spirit of Ecstasy soaring (video)

RollsRoyce Wraith picks gears based on GPS position, would rather you avoid the Broads

Many Rolls-Royce drivers are used to effortless speed between the big engines and smooth suspensions. The automaker's new Wraith coupe could iron out what few of those wrinkles are left through a clever use of GPS for the transmission. Its eight-speed ZF automatic gearbox relies on positioning to pick gears in advance, gauging the situation down to the exact stretch of road: it can see the need for a shorter gear at the upcoming corner, for example. Other tech upgrades aren't quite as fresh, although we're sure that less traditionalist Rolls drivers won't mind a heads-up display, voice command support and the infotainment system's multi-touch trackpad. The Wraith's €245,000 ($318,745) price and late 2013 availability will likely be too much to endure if all you're looking for is seamless shifting -- they may, however, provide some consolation for missing out on that LaFerrari.

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Source: http://www.engadget.com/2013/03/06/rolls-royce-wraith-picks-gears-using-gps/

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China destroys Ikea cake, Nestle chocolate

(AP) ? Chinese authorities say they have destroyed nearly two tons of chocolate cake imported by Sweden's Ikea for violating food quality standards.

The Shanghai quarantine bureau said this week that Kraft cream cheese and 2.7 tons of Nestle chocolate bars also were among dozens of imported products destroyed in its latest round of quality inspections.

Chinese authorities have stepped up food inspections in recent years after a series of scandals over fake or shoddy goods.

The disclosure in December that suppliers of KFC violated rules on drugs use in poultry caused sales for the restaurant chain to plunge. KFC estimated sales in January dropped 37 percent and the company announced tighter quality control measures in an effort to win back customers.

The Shanghai quarantine bureau said it destroyed 1,872 kilos (4,100 pounds) of chocolate almond cake imported by Ikea that it said had excessive levels of coliform bacteria.

Ikea spokeswoman Ylva Magnusson said the cakes were destroyed in November and December but the company's head office had only found out about it on Monday.

"The product was stopped and destroyed. So none of the cakes made it to our restaurants," she said.

The cake made by a Swedish supplier is sold in Ikea stores in a majority of the countries where it operates. Magnusson said the company is looking into whether the cake should be withdrawn from sale elsewhere.

The Nestle chocolate contained too much sorbitol, a sweetener that in large amounts can cause bowel problems, the agency said in a statement.

Phone calls to spokespeople for Nestle and Kraft in China were not answered.

___(equals)

Shanghai quarantine bureau: http://jckspaqj.aqsiq.gov.cn/

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/f70471f764144b2fab526d39972d37b3/Article_2013-03-05-AS-China-Food-Quality/id-9c532a50036043618a5bebbea80ce61e

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In South Florida, Venezuelans react to Hugo Ch?vez?s death

In the South Florida enclaves crowded with Venezuelans who fled President Hugo Ch?vez?s regime, Ch?vez?s death Tuesday afternoon prompted spontaneous gatherings in familiar places. Local politicians weighed in offering reactions and predictions. And television and radio stations ramped up their news coverage, in what could be a preview of how Miami reacts to the eventual death of Fidel Castro.

Several news crews broadcast live in the early evening from Doral, home to scores of Venezuelans and a Venezuelan-born mayor. Many gathered at El Arepazo, a popular Venezuelan restaurant, waving Venezuelan flags and cheering ? Venezuela presente? ? Venezuela is present.

But the early crowds appeared thinner than in Weston, another city with a high concentration of Venezuelans.

El Arepazo 2, inside a strip plaza off Weston Road, began filling up with customers Tuesday evening, some of them women with baby strollers, others men drinking Polar beer ? a Venezuelan brand. They clustered around the television. A TV news crew interviewed customers. Later, the crowd spilled out into the street.

News of Ch?vez?s death was welcomed with cheers and hope for a more Democratic future. Customers gathered around a flat screen TV tuned to Telemundo?s live broadcast of the news from Venezuela. Others waited in line for arepas, their gazes fixed on the TV.

Daniela Calzadilla and her sister, Corina, toasted Ch?vez?s death with Polar beer in styrofoam cups. The women hoisted a small Venezuelan flag.

?We hope this is the path to return our democracy and that hopefully we can have the same country we once had,? said Daniela, who moved from Caracas five years ago. She left because crime in the Venezuelan capital skyrocketed under Ch?vez?s leadership, she said, and career opportunities dwindled.

Corina Calzadilla, who moved to Weston a decade ago, said she felt bad for Ch?vez?s children. ?The death of a parent is painful,? she said.

The sisters said they plan to return to Venezuela to vote in new presidential elections.

At a nearby table, Oscar P?rez, 31, said he was celebrating ?the birth of a new country.?

?There?s so much happiness,? said P?rez, who moved to Weston from Caracas the year Ch?vez took power. ?We?ve been waiting 14 years. I?ve seen how he ruined the country. It?s anarchy.?

P?rez?s brother, Armando, 29, said his joy was tempered with concern about reaction among pro-Ch?vez supporters, known as chavistas, back home.

?This is the first step to big change,? he said. ?I hope nothing bad happens, and that ignorant people don?t resort to violence.?

P?rez said he looks forward to new elections in Venezuela.

And though Ch?vez built a political base in Venezuela, Armando P?rez said he doesn?t believe the movement Ch?vez created will survive without its populist and charismatic leader.

? Chavismo without Chavez doesn?t exist,? he said.

Though the P?rez brothers have lived nearly half their lives in South Florida, they have friends and relatives back in Venezuela.

Carlos Marino, 63, watched the TV with the Perezes. All three are car salesman for the nearby Rick Case dealership.

They broke into occasional song, including popular tunes Viva Venezuela and Yo Me Quedo en Venezuela (I?m staying in Venezuela).

Some customers were just hearing the news.

? Es verdad,? Marino said happily. It?s true.

?I never wish anyone death,? he continued, ?but in this case I did. He poisoned the Caribbean.?

Marino lives in Miami Lakes. He moved to south Florida 15 year ago, he said, because he did not like Ch?vez.

?I have a new life here,? he said, ?but I always wish happiness and liberty for my people.?

Marino said the first person he called when hearing the news was his uncle in Margarita, an island off the northern coast of Venezuela. His uncle was screaming with joy, Marino said.

Miami Herald writer Paradise Afshar contributed to this report.

Source: http://www.miamiherald.com/2013/03/05/3268693/in-south-florida-venezuelans-react.html

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Raspberry Pi coming in limited edition blue, you'll have to win it to own it

Raspberry Pi coming in limited edition blue, you'll have to win it to own it

The Raspberry Pi has been on sale for just over a year. Key distributor RS Components wants to celebrate the tiny computer's first birthday with more than just a greeting card, though. It's producing a limited edition Model B, the Blue Pi, with a blue circuit board and a suitably-hued case. The mini PC is guaranteed to stand out in any hobbyist project, provided it's not hidden in a box. There's only one catch: you can't buy one. RSC is donating a batch to good causes, and only 1,000 are up for grabs in giveaways running between now and June. Those who make a convincing argument for Blue Pi ownership will accordingly be part of an exclusive club -- and the envy of any Raspberry Pi owner who's been bored with plain green.

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Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/ld274bNfWOs/

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Scientists discover new mechanisms for relaxing airways using bitter tasting substances

Mar. 5, 2013 ? That kale and bitter melon you are eating may someday save your life. An interdisciplinary team of scientists at the University of Massachusetts Medical School have taken a step forward in understanding how the substances that give some foods their bitter flavor also act to reverse the contraction of airway cells, a process known as bronchodilation. This effect may one day be harnessed to provide improved treatments for airway obstructive diseases such as asthma and chronic obstructive pulmonary disease.

The findings were published on March 5 in the open access journal PLOS Biology.

"I am excited that someday, with more research, there may be a new class of bronchodilators which are able to reverse an asthma attack quicker and with fewer side effects than is currently available to patients," said Ronghua ZhuGe, PhD, associate professor of microbiology and physiological systems and senior author of the study.

The sense of taste is mediated by taste receptor cells bundled in our taste buds. Most humans experience five types of tastes: sweet, salty, sour, bitter and savory. Bitter taste receptors most likely evolved to help alert the body to potentially harmful foods that have spoiled or are toxic. The receptors have long been thought to only exist in certain cells present in the tongue. Over the last few years, however, scientists have come to realize that these receptors are present in many other cells throughout the body. Specifically, bitter taste receptors on smooth muscle cells in the airway act to relax the cells when exposed to bitter-tasting substances.

A hallmark of an asthma attack is excessive contraction of smooth muscle cells, which causes narrowing of the airways and subsequent breathing difficulties. The fact that bitter substances can relax these smooth muscle cells suggests that they may have the potential to halt asthma attacks and in fact could even be an improvement over current treatments since the relaxation effects are quite fast. Indeed, experiments in mice suggest that the effects are stronger.

However, the mechanisms by which bitter taste receptor activation causes a cell to relax were unknown. To help unravel these mechanisms, Dr. ZhuGe and colleagues examined the effect of bitter substances on the contraction of airways and in single isolated cells.

During an asthma attack, channels on the membrane of smooth muscle cells in the airways open. This allows calcium to flow into the cell, causing it to contract. When the cells contract, the airway becomes narrower and makes breathing more difficult. Dr. ZhuGe and colleagues determined that bitter substances act by shutting down these calcium channels, allowing bronchodilation.

Bitter taste receptors, like most receptors, span the plasma membrane of the cell. Part of the receptor is outside the cell, able to bind (and hence "sense") bitter substances outside the cell. When a bitter compound binds to a bitter taste receptor, the receptor releases a G-protein, which then splits into two parts: a G alpha subunit and G beta-gamma dimer. "It is the G beta-gamma dimer that likely acts to close the calcium channels on the plasma membrane," said Kevin Fogarty, director of the biomedical imaging group in the program in molecular medicine at UMMS, and a co-author of the study. "Once the channels are closed, the calcium level returns to normal and the cell relaxs," he said. "This ends the asthma attack."

"With this new understanding of how bitter substances are able to relax airways, we can focus our attention on studying these receptors and on finding even more potent bitter compounds with the potential to be used therapeutically to end asthma attacks," said Dr. ZhuGe.

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The above story is reprinted from materials provided by University of Massachusetts Medical School, via EurekAlert!, a service of AAAS.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Cheng-Hai Zhang, Lawrence M. Lifshitz, Karl F. Uy, Mitsuo Ikebe, Kevin E. Fogarty, Ronghua ZhuGe. The Cellular and Molecular Basis of Bitter Tastant-Induced Bronchodilation. PLoS Biology, 2013; 11 (3): e1001501 DOI: 10.1371/journal.pbio.1001501

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_health/~3/ql1thaa3GO8/130305174528.htm

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Tuesday, March 5, 2013

Researchers discover how to shutdown cancer's powerful master protein

Monday, March 4, 2013

The powerful master regulatory transcription factor called Bcl6 is key to the survival of a majority of aggressive lymphomas, which arise from the B-cells of the immune system. The protein has long been considered too complex to target with a drug since it is also crucial to the healthy functioning of many immune cells in the body, not just B cells gone bad.

But now, in the journal Nature Immunology, researchers at Weill Cornell Medical College report that it is possible to shut down Bcl6 in the cancer, known as diffuse large B-cell lymphoma (DLBCL), while not affecting its vital function in T cells and macrophages that are needed to support a healthy immune system.

"The finding comes as a very welcome surprise," says the study's lead investigator, Dr. Ari Melnick, Gebroe Family Professor of Hematology/Oncology and director of the Raymond and Beverly Sackler Center for Biomedical and Physical Sciences at Weill Cornell.

"This means the drugs we have developed against Bcl6 are more likely to be significantly less toxic and safer for patients with this cancer than we realized," says Dr. Melnick, who is also a hematologist-oncologist at NewYork-Presbyterian Hospital/Weill Cornell Medical Center.

If Bcl6 is completely inhibited, patients might suffer from systemic inflammation and atherosclerosis. Weill Cornell researchers conducted this new study to help clarify possible risks, as well as to understand how Bcl6 controls the various aspects of the immune system.

DLBCL is the most common subtype of non-Hodgkin lymphoma -- the seventh most frequently diagnosed cancer -- and many of these patients are resistant to currently available treatments.

"Scientists have been searching for the right answer to treat this difficult lymphoma, which, after initial treatment, can be at high risk of relapse and resistant to current therapies," Dr. Melnick says. "Believing that Bcl6 could not be targeted, some researchers have been testing alternative therapeutic approaches. This study strongly supports the notion of using Bcl6-targeting drugs."

In fact, the findings in this study were inspired from preclinical testing of two Bcl6-targeting agents that Dr. Melnick and his Weill Cornell colleagues have developed to treat DLBCLs. These experimental drugs are RI-BPI, a peptide mimic, and the small molecule agent 79-6.

Dr. Melnick says the discovery that a master regulatory transcription factor can be targeted offers implications beyond just treating DLBCL. Recent studies from Dr. Melnick and others have revealed that Bcl6 plays a key role in the most aggressive forms of acute leukemia, as well as certain solid tumors.

Transcription factors are responsible for either inhibiting or promoting the expression of genes, and master regulatory transcription factors are the equivalent of the CPU of a computer ? their actions regulate thousands of genes in different kinds of cells. For example, Bcl6 can control the type of immune cell that develops in the bone marrow -- playing many roles in the development of B cells, T cells, macrophages and other cells -- including a primary and essential role in enabling B-cells to generate specific antibodies against pathogens.

"When cells lose control of Bcl6, lymphomas develop in the immune system. Lymphomas are 'addicted' to Bcl6, and therefore Bcl6 inhibitors powerfully and quickly destroy lymphoma cells," Dr. Melnick says.

The big surprise in the current study is that rather than functioning as a single molecular machine, Bcl6 instead seems to function more like a Swiss Army knife, using different tools to control different cell types. This multi-function paradigm could represent a general model for the functioning of other master regulatory transcription factors.

"In this analogy, the Swiss Army knife, or transcription factor, keeps most of its tools folded, opening only the one it needs in any given cell type," Dr. Melnick says. "For B cells, it might open and use the knife tool; for T cells, the cork screw; for macrophages, the scissors. The amazing thing from a medical standpoint is that this means that you only need to prevent the master regulator from using certain tools to treat cancer. You don't need to eliminate the whole knife," he says. "In fact, we show that taking out the whole knife is harmful since the transcription factor has many other vital functions that other cells in the body need."

Prior to these study results, it was not known that a master regulator could separate its functions so precisely.

"Now we know we can take out a specific tool -- to shut down a specific part of the protein -- that causes the disease we want to treat."

Researchers hope this will be a major benefit to the treatment of DLBCL and perhaps other disorders that are influenced by Bcl6 and other master regulatory transcription factors.

###

Weill Cornell Medical College: http://www.med.cornell.edu/index.html

Thanks to Weill Cornell Medical College for this article.

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Source: http://www.labspaces.net/127106/Researchers_discover_how_to_shutdown_cancer_s_powerful_master_protein

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